Crystal structures of Na+ ,K+ -ATPase reveal the mechanism that converts the K+ -bound form to Na+ -bound form and opens and closes the cytoplasmic gate.

Kanai, Ryuta; Vilsen, Bente; Cornelius, Flemming; Toyoshima, Chikashi

Crystal structures of Na⁺ ,K⁺ -ATPase reveal the mechanism that converts the K⁺ -bound form to Na⁺ -bound form and opens and closes the cytoplasmic gate.

Kanai, Ryuta; Vilsen, Bente; Cornelius, Flemming; Toyoshima, Chikashi.

Affiliation

Kanai R; Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo-ku, Japan.
Vilsen B; Department of Biomedicine, Aarhus University, Denmark.
Cornelius F; Department of Biomedicine, Aarhus University, Denmark.
Toyoshima C; Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo-ku, Japan.

FEBS Lett ; 597(15): 1957-1976, 2023 08.

Article in En | MEDLINE | ID: mdl-37357620

Subject(s)

Potassium; Sodium-Potassium-Exchanging ATPase; Sodium-Potassium-Exchanging ATPase/chemistry; Cytoplasm/metabolism; Ions/metabolism; Cytosol/metabolism; Cell Membrane/metabolism; Potassium/metabolism

Key words

Na+,K+-ATPase; X-ray crystallography; cryo-electron microscopy; occlusion; sodium pump

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Potassium / Sodium-Potassium-Exchanging ATPase Language: En Journal: FEBS Lett Year: 2023 Document type: Article Affiliation country: Japan

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