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Effect of Amphotericin B on the Thermodynamic Properties and Surface Morphology of the Pulmonary Surfactant Model Monolayer during Respiration.
Wang, Juan; Wang, Jia; Wang, Xinzhong; Wang, Zhen.
Affiliation
  • Wang J; Shaanxi Engineering Research Center of Controllable Neutron Source, School of Electronic Information, Xijing University, Xi'an 710123, China.
  • Wang J; Shaanxi Engineering Research Center of Controllable Neutron Source, School of Electronic Information, Xijing University, Xi'an 710123, China.
  • Wang X; Xi'an Key Laboratory of Human-Machine Integration and Control Technology for Intelligent Rehabilitation, School of Computer Science, Xijing University, Xi'an 710123, China.
  • Wang Z; Xi'an Key Laboratory of Human-Machine Integration and Control Technology for Intelligent Rehabilitation, School of Computer Science, Xijing University, Xi'an 710123, China.
Molecules ; 28(12)2023 Jun 18.
Article in En | MEDLINE | ID: mdl-37375395
ABSTRACT
During the COVID-19 pandemic, the treatment of pulmonary fungal infection faced noteworthy challenges. Amphotericin B has shown promising therapeutic effects as an inhalation treatment for pulmonary fungal infections, especially those associated with the COVID-19 virus, due to its rare resistance. However, because the drug frequently produces renal toxicity, its effective dose is limited in clinical use. In this work, the DPPC/DPPG mixed monolayer was used as the pulmonary surfactant monolayer to study the interaction between amphotericin B and the pulmonary surfactant monolayer during inhalation therapy using the Langmuir technique and atomic force microscopy. The effects of different molar ratios of AmB on the thermodynamic properties and surface morphology of the pulmonary surfactant monolayer at different surface pressures was evaluated. The results showed that when the molar ratio of AmB to lipids in the pulmonary surfactant was less than 11, the main intermolecular force was attractive at a surface pressure greater than 10 mN/m. This drug had little effect on the phase transition point of the DPPC/DPPG monolayer, but decreased the height of the monolayer at 15 mN/m and 25 mN/m. When the molar ratio of AmB to lipids was greater than 11, the intermolecular force was mainly repulsive at a surface pressure greater than 15 mN/m, and AmB increased the height of the DPPC/DPPG monolayer at both 15 mN/m and 25 mN/m. These results are helpful in understanding the interaction between the pulmonary surfactant model monolayer and different doses of drugs at various surface tensions during respiration.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pulmonary Surfactants / COVID-19 Limits: Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2023 Document type: Article Affiliation country: China

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pulmonary Surfactants / COVID-19 Limits: Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2023 Document type: Article Affiliation country: China