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Amamine, an isoquinoline alkaloid from the Kitasatospora sp. HGTA304.
Kawahara, Teppei; Ueda, Marin; Kishimoto, Naoki; Yasutake, Tae; Misumi, Shogo; Devkota, Hari Prasad; Wada, Mikiyo.
Affiliation
  • Kawahara T; Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, 862-0973, Japan. teppei@kumamoto-u.ac.jp.
  • Ueda M; Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, 862-0973, Japan.
  • Kishimoto N; Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, 862-0973, Japan.
  • Yasutake T; Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, 862-0973, Japan.
  • Misumi S; Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, 862-0973, Japan.
  • Devkota HP; Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, 862-0973, Japan.
  • Wada M; Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, 862-0973, Japan.
J Antibiot (Tokyo) ; 76(10): 623-625, 2023 10.
Article in En | MEDLINE | ID: mdl-37386154
Amamine (1), a new isoquinoline alkaloid, was isolated from the culture extract of an actinomycete Kitasatospora sp. HGTA304. The structure of 1 was determined by NMR and MS analyses in combination with UV data. Compound 1 displayed α-glucosidase inhibitory potential (IC50 value of 56 µM) compared with acarbose (IC50 value of 549 µM) as standard.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Streptomycetaceae / Alkaloids / Antineoplastic Agents Language: En Journal: J Antibiot (Tokyo) Year: 2023 Document type: Article Affiliation country: Japan Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Streptomycetaceae / Alkaloids / Antineoplastic Agents Language: En Journal: J Antibiot (Tokyo) Year: 2023 Document type: Article Affiliation country: Japan Country of publication: United kingdom