Your browser doesn't support javascript.
loading
Acute myeloid leukemia with NUP98::RARG resembling acute promyelocytic leukemia accompanying ARID1B gene mutation.
Wu, Danyang; Gao, Ran.
Affiliation
  • Wu D; Department of Hematology, The First Hospital of China Medical University, Shenyang, People's Republic of China.
  • Gao R; Department of Hematology, The First Hospital of China Medical University, Shenyang, People's Republic of China.
Hematology ; 28(1): 2227495, 2023 Dec.
Article in En | MEDLINE | ID: mdl-37387408
ABSTRACT
In this study, we present a case of acute myeloid leukemia characterized by the t(11;12)(p15;q13) translocation, exhibiting clinical, immunophenotypical, and morphological features consistent with acute promyelocytic leukemia (APL). The RNA sequencing analysis of the patient's bone marrow samples revealed the presence of the NUP98-retinoic acid receptor gamma (RARG) (NUP98RARG) gene resulting from the translocation. Furthermore, the presence of a mutation in the ARID1B gene in the patient under study indicates a potential association with resistance to all-trans retinoic acid (ATRA).
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Leukemia, Promyelocytic, Acute Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Hematology Journal subject: HEMATOLOGIA Year: 2023 Document type: Article
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Leukemia, Promyelocytic, Acute Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Hematology Journal subject: HEMATOLOGIA Year: 2023 Document type: Article