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Emerging small molecular inhibitors as targeted therapies for high-risk acute myeloid leukemias.
Sahasrabudhe, Kieran D; Albrethsen, Mary; Mims, Alice S.
Affiliation
  • Sahasrabudhe KD; Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
  • Albrethsen M; Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
  • Mims AS; Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
Expert Rev Hematol ; 16(9): 671-684, 2023.
Article in En | MEDLINE | ID: mdl-37405412
INTRODUCTION: Acute myeloid leukemia (AML) is an aggressive disease which has traditionally been treated with intensive chemotherapy. Survival in patients with high-risk cytogenetic and molecular subsets has been poor with this approach due to suboptimal responses seen with intensive chemotherapy and due to many patients with higher risk disease being older and unable to tolerate intensive therapies. In recent years, several targeted therapies have been under investigation for patients with high-risk AML subsets. AREAS COVERED: This review covers four different subsets of high-risk AML including TP53-mutated, KMT2A-rearranged, FLT3-mutated, and secondary AML developing after prior hypomethylating agent exposure. The research discussed in this review focuses on small molecule inhibitors that have been studied in the treatment of these high-risk AML subsets. EXPERT OPINION: There are several small molecule inhibitors that have demonstrated promise in these high-risk AML subsets. Longer follow-up and ongoing investigation are needed to continue to optimize therapy for patients with high-risk AML.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute Type of study: Etiology_studies / Risk_factors_studies Limits: Humans Language: En Journal: Expert Rev Hematol Journal subject: HEMATOLOGIA Year: 2023 Document type: Article Affiliation country: United States Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute Type of study: Etiology_studies / Risk_factors_studies Limits: Humans Language: En Journal: Expert Rev Hematol Journal subject: HEMATOLOGIA Year: 2023 Document type: Article Affiliation country: United States Country of publication: United kingdom