Antibiotic Combination Therapy for Severe Scrub Typhus: Is It Necessary?
Infect Chemother
; 55(2): 179-184, 2023 Jun.
Article
in En
| MEDLINE
| ID: mdl-37407239
ABSTRACT
Scrub typhus can be adequately treated with doxycycline or azithromycin unless it is treated too late. Such cases present as severe scrub typhus, and their treatment remains a challenging problem. In this article, we briefly review the literature on the treatment of scrub typhus and the limitations of the combination of doxycycline and azithromycin. Several options are suggested for further study in the treatment of severe scrub typhus (such as encephalitis, myocarditis, and pneumonia), including dose escalation of doxycycline, the adjuvant use of steroids, the selective use of beta-lactam antibiotics, and the use of tigecycline.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Infect Chemother
Year:
2023
Document type:
Article