Human Leukocyte Antigen Polymorphism HLA-A*24:02 is Associated with Acute Liver Disease in HBV-Infected Han Chinese Adults.
Immunol Invest
; 52(6): 767-778, 2023 Nov.
Article
in En
| MEDLINE
| ID: mdl-37417317
ABSTRACT
BACKGROUND:
Whether polymorphic Human Leukocyte Antigen (HLA)-A, HLA-B and HLA-DRB1 alleles were associated with acute liver disease after hepatitis B virus (HBV) infections was investigated.METHODS:
In this study, from initially 100 participants in each group, HLA-A, HLA-B and HLA-DRB1 sequences were available from 86 acute hepatitis B (AHB) patients and from 84 HBV-resistant individuals (controls), using sequencing-based typing allele groups and alleles that exhibited differences in distribution between the case and control groups were subjected to chi-squared and logistic regression analyses to identify those associated with AHB. A dose response analysis was also performed on the effect of HLA-A*2402 allele number on acute liver disease following HBV infection.RESULTS:
The frequency distribution of HLA-B and HLA-DRB1 alleles in the control group were in Hardy-Weinberg Equilibrium (P > .05). HLA-A*2402 (χ2 = 6.949, P = .008) occurred most frequently in the AHB and HLA-DRB1*1202 (χ2 = 7.768, P = .005) in the control group. With adjustment for sex, the logistic regression model showed that the HLA-A*2402 allele was significantly associated with AHB liver injury (P = .0326, OR = 2.270, 95% CI 1.070-4.816), whereas the other HLA-A, HLA-B, and HLA-DRB1 alleles were not (P > .05). A linear response was observed for the association between HLA-A*2402 allele number and acute liver disease after HBV infections (χ2 = 4.428, P = .025).CONCLUSION:
The HLA-A*2402 allele may influence the severity of the cellular response to HBV infection, increasing the elimination of HBV-infected hepatocytes. The HLA-A*2402 allele may be a potential screening marker for identifying people or regional populations in China at higher risk of acute liver disease following HBV infection.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
HLA-A Antigens
/
Hepatitis B
Type of study:
Risk_factors_studies
Limits:
Adult
/
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Immunol Invest
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2023
Document type:
Article
Affiliation country:
China