Reaction of N,N-disubstituted alpha-aminomethyleneketones with tosyl isocyanate. Synthesis of amino-disubstituted 2-acyl-3-amino-N-tosylpropenamides, N,N-(3-amino-1-alkyl-2-propenylidene) and N,N-[2-(aminomethylene)cyclohexylidene]tosylamides.
Farmaco Sci
; 41(7): 539-47, 1986 Jul.
Article
in En
| MEDLINE
| ID: mdl-3743747
ABSTRACT
The reaction of N,N-disubstituted open-chain and cyclohexane alpha-aminomethyleneketones (I) and (II) with p-toluenesulfonyl (tosyl) isocyanate gave amino-disubstituted 2-acyl-3-amino-N-tosylpropenamides (III) and/or N,N-(3-amino-1-alkyl-2-propenylidene) and N,N-[2-(aminomethylene)-cyclohexylidene] tosylamides (IV) and (V), the final product being related to the carbon and nitrogen substituents of the enaminone. The evaluation of the hypoglycemic activity concerning some of the above compounds gave no interesting results.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tosyl Compounds
/
Cyclohexanes
/
Amides
/
Hypoglycemic Agents
/
Methylamines
Limits:
Animals
Language:
En
Journal:
Farmaco Sci
Year:
1986
Document type:
Article