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Effect of COVID-19 inactivated vaccine on peripheral blood anti-ß2-GPI antibody and outcomes in vitro fertilization-embryo transplantation.
Zhou, Huiling; Zou, Yilu; Guo, Yujia; Lv, Xiaoting; Chen, Jiajing; Guo, Xinxin; Liu, Qicai.
Affiliation
  • Zhou H; Department of Reproductive Medicine Center, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China.
  • Zou Y; Department of Reproductive Medicine Center, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China; Fujian Provincial Key Laboratory of Stem Cell Engineering and Regenerative Medicine, Fuzhou 350004, Fujian, China.
  • Guo Y; Department of Reproductive Medicine Center, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China.
  • Lv X; Department of Respiratory and Critical Care Medicine, Research Laboratory of the Respiratory System Diseases, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China.
  • Chen J; Department of Reproductive Medicine Center, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China.
  • Guo X; Department of Reproductive Medicine Center, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China; Fujian Provincial Key Laboratory of Stem Cell Engineering and Regenerative Medicine, Fuzhou 350004, Fujian, China. Electronic address: guoxin90@fjmu.edu.cn.
  • Liu Q; Department of Reproductive Medicine Center, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China. Electronic address: liuqc2000@yeah.net.
Int Immunopharmacol ; 122: 110596, 2023 Sep.
Article in En | MEDLINE | ID: mdl-37441812
ABSTRACT
Corona Virus Disease 2019 (COVID-19) is an acute respiratory infection and a global public health event. The level of aß2GPI is significantly up-regulated in COVID-19 patients. The impact of inactivated vaccination against COVID-19 on aß2GPI and in vitro fertilization and embryo transfer (IVF-ET) remains unknown amidst the universal administration of COVID-19 vaccines. We conducted a retrospective study to assess the impact of COVID-19 inactivated vaccination on aß2GPI levels and its effect on superovulation and pregnancy outcomes. We found aß2GPI level is significantly up-regulated after vaccination. There was no statistical difference in mature egg rate, 2PN fertilization rate, day 3 high-quality embryo rate, blastocyst formation rate, embryo implantation rate and miscarriage rate between the vaccine group and control group. Our findings showed vaccination with COVID-19 inactivated vaccine can elevate the level of aß2GPI in peripheral blood but have no effect on the outcomes of controlled ovarian hyperstimulation and pregnancy in IVF-ET.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Observational_studies Limits: Female / Humans / Pregnancy Language: En Journal: Int Immunopharmacol Journal subject: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Year: 2023 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Observational_studies Limits: Female / Humans / Pregnancy Language: En Journal: Int Immunopharmacol Journal subject: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Year: 2023 Document type: Article Affiliation country: China