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Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR signalling complex.
Strickson, Sam; Houslay, Kirsty F; Negri, Victor A; Ohne, Yoichiro; Ottosson, Tomas; Dodd, Roger B; Huntington, Catherine Chaillan; Baker, Tina; Li, Jingjing; Stephenson, Katherine E; O'Connor, Andy J; Sagawe, J Sophie; Killick, Helen; Moore, Tom; Rees, D Gareth; Koch, Sofia; Sanden, Caroline; Wang, Yixin; Gubbins, Elise; Ghaedi, Mahboobe; Kolbeck, Roland; Saumyaa, Saumyaa; Erjefält, Jonas S; Sims, Gary P; Humbles, Alison A; Scott, Ian C; Romero Ros, Xavier; Cohen, E Suzanne.
Affiliation
  • Strickson S; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Houslay KF; These authors contributed equally to this work.
  • Negri VA; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Ohne Y; These authors contributed equally to this work.
  • Ottosson T; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Dodd RB; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.
  • Huntington CC; Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Baker T; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK.
  • Li J; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK.
  • Stephenson KE; Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • O'Connor AJ; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Sagawe JS; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Killick H; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Moore T; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Rees DG; Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Koch S; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Sanden C; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK.
  • Wang Y; Imaging & Data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
  • Gubbins E; Experimental Medical Sciences, Lund University, Lund, Sweden.
  • Ghaedi M; Medetect AB, Lund, Sweden.
  • Kolbeck R; Imaging & Data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
  • Saumyaa S; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Erjefält JS; Bioscience COPD/IPF, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.
  • Sims GP; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.
  • Humbles AA; Current: Spirovant Sciences, Philadelphia, PA, USA.
  • Scott IC; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
  • Romero Ros X; Experimental Medical Sciences, Lund University, Lund, Sweden.
  • Cohen ES; Allergology and Respiratory Medicine, Lund University, Skåne University Hospital, Lund, Sweden.
Eur Respir J ; 62(3)2023 09.
Article in En | MEDLINE | ID: mdl-37442582
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pulmonary Disease, Chronic Obstructive / Interleukin-33 Type of study: Etiology_studies / Prognostic_studies Limits: Humans Language: En Journal: Eur Respir J Year: 2023 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pulmonary Disease, Chronic Obstructive / Interleukin-33 Type of study: Etiology_studies / Prognostic_studies Limits: Humans Language: En Journal: Eur Respir J Year: 2023 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom