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Photons Induce Vesicular Exocytotic Release of Glutamate in a Power-Dependent Way.
Cervetto, Chiara; Amaroli, Andrea; Amato, Sarah; Gatta, Elena; Diaspro, Alberto; Maura, Guido; Signore, Antonio; Benedicenti, Stefano; Marcoli, Manuela.
Affiliation
  • Cervetto C; Department of Pharmacy, Section of Pharmacology and Toxicology, University of Genova, Viale Cembrano 4, 16148 Genova, Italy.
  • Amaroli A; Interuniversity Center for the Promotion of the 3Rs Principles in Teaching and Research (Centro 3R), 56122 Pisa, Italy.
  • Amato S; Department of Earth, Environment and Life Sciences, University of Genova, Viale Benedetto XV 5, 16132 Genova, Italy.
  • Gatta E; Department of Pharmacy, Section of Pharmacology and Toxicology, University of Genova, Viale Cembrano 4, 16148 Genova, Italy.
  • Diaspro A; DIFILAB, Department of Physics, University of Genova, Via Dodecaneso 33, 16146 Genova, Italy.
  • Maura G; DIFILAB, Department of Physics, University of Genova, Via Dodecaneso 33, 16146 Genova, Italy.
  • Signore A; Nanoscopy, Nanophysics, Istituto Italiano di Tecnologia-IIT, Via Morego 30, 16133 Genova, Italy.
  • Benedicenti S; Biophysics Institute, National Research Council-CNR, Via de Marini, 6, 16149 Genova, Italy.
  • Marcoli M; Department of Pharmacy, Section of Pharmacology and Toxicology, University of Genova, Viale Cembrano 4, 16148 Genova, Italy.
Int J Mol Sci ; 24(13)2023 Jul 01.
Article in En | MEDLINE | ID: mdl-37446155
Increasing evidence indicates that photobiomodulation, based on tissue irradiation with photons in the red to near-infrared spectrum, may be an effective therapeutic approach to central nervous system disorders. Although nervous system functionality has been shown to be affected by photons in animal models, as well as in preliminary evidence in healthy subjects or in patients with neuropsychiatric disorders, the mechanisms involved in the photobiomodulation effects have not yet been clarified. We previously observed that photobiomodulation could stimulate glutamate release. Here, we investigate mechanisms potentially involved in the glutamate-releasing effect of photons from adult mouse cerebrocortical nerve terminals. We report evidence of photon ability to induce an exocytotic vesicular release of glutamate from the terminals of glutamatergic neurons in a power-dependent way. It can be hypothesized that photobiomodulation, depending on the potency, can release glutamate in a potentially neurotoxic or physiological range.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Photons / Glutamic Acid Type of study: Prognostic_studies Limits: Animals Language: En Journal: Int J Mol Sci Year: 2023 Document type: Article Affiliation country: Italy Country of publication: Switzerland

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Photons / Glutamic Acid Type of study: Prognostic_studies Limits: Animals Language: En Journal: Int J Mol Sci Year: 2023 Document type: Article Affiliation country: Italy Country of publication: Switzerland