Disease course of ulcerative proctitis in children: A population-based study on behalf of the SIGENP IBD Group.
Dig Liver Dis
; 56(1): 70-76, 2024 Jan.
Article
in En
| MEDLINE
| ID: mdl-37481430
ABSTRACT
BACKGROUND:
The natural history of ulcerative proctitis (UP) has been poorly investigated in children.AIMS:
We aimed to compare the disease course of children with UP at diagnosis to the other locations and to identify extension predictors.METHODS:
This was a multicenter, observational study carried out from data prospectively entered in the SIGENP-IBD-Registry. Children with ulcerative colitis (UC) diagnosis and at least 1-year follow-up were included. On the basis of Paris classification UP patients were identified and compared with the other locations.RESULTS:
872 children were enrolled (median age at diagnosis 11.2 years; M/F 426/446), of whom 78 (9%) with UP. Kaplan-Meier analysis demonstrated increased cumulative probabilities of disease extension in the E1 group [1 year 20.3%; 5 years 52.7%; 10 years 72.4%] compared to E3 group [1 year 8.5%; 5 years 24.9% and 10 years 60.1%, p=0.001]. No differences were observed comparing E1 and E2 groups [p=0.4]. Cumulative probabilities of surgery at 1, 5 and 10 years were 1.3, 2.8 and 2.8% in the E1 group and 2.5, 8 and 12.8% in the E2-E3-E4 group, respectively (p=0.1). Cox regression analysis demonstrated that PUCAI>35 at diagnosis was associated with endoscopic extension (HR=4.9; CI 95% 1.5-15.2, p=0.006).CONCLUSIONS:
UP is associated with similar short and long-term outcomes compared to other locations.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Proctitis
/
Colitis, Ulcerative
Type of study:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
Limits:
Child
/
Humans
Language:
En
Journal:
Dig Liver Dis
Journal subject:
GASTROENTEROLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Italy