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Prognostic scores for patients with salivary adenoid cystic carcinoma without lymph node metastasis.
Shimoda, Hikari; Teshima, Masanori; Murase, Takayuki; Nagao, Toshitaka; Kusafuka, Kimihide; Nakaguro, Masato; Urano, Makoto; Taguchi, Ken-Ichi; Yamamoto, Hidetaka; Kano, Satoshi; Tada, Yuichiro; Tsukahara, Kiyoaki; Okami, Kenji; Onitsuka, Tetsuro; Fujimoto, Yasushi; Kawakita, Daisuke; Sakurai, Kazuo; Hanai, Nobuhiro; Nagao, Toru; Kawata, Ryo; Hato, Naohito; Nibu, Ken-Ichi; Inagaki, Hiroshi.
Affiliation
  • Shimoda H; Department of Otolaryngology­Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan; Department of Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
  • Teshima M; Department of Otolaryngology­Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Murase T; Department of Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
  • Nagao T; Department of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan.
  • Kusafuka K; Department of Pathology, Shizuoka General Hospital, Shizuoka, Japan.
  • Nakaguro M; Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan.
  • Urano M; Department of Diagnostic Pathology, Bantane Hospital, Fujita Health University School of Medicine, Nagoya, Japan.
  • Taguchi KI; Department of Pathology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.
  • Yamamoto H; Department of Anatomic Pathology, Graduate of School of Medical Science, Kyushu University, Fukuoka, Japan.
  • Kano S; Department of Otolaryngology­Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
  • Tada Y; Department of Head and Neck Oncology and Surgery, International University of Health and Welfare, Mita Hospital, Tokyo, Japan.
  • Tsukahara K; Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan.
  • Okami K; Department of Otolaryngology­Head and Neck Surgery, Tokai University School of Medicine, Isehara, Japan.
  • Onitsuka T; Division of Head and Neck Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
  • Fujimoto Y; Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan; Department of Otorhinolaryngology-Head and Neck Surgery, Aichi Medical University School of Medicine, Nagakute, Japan.
  • Kawakita D; Department of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
  • Sakurai K; Department of Otorhinolaryngology, Fujita Health University, Okazaki Medical Center, Okazaki, Japan.
  • Hanai N; Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
  • Nagao T; Department of Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
  • Kawata R; Department of Otorhinolaryngology­Head and Neck Surgery, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
  • Hato N; Department of Otolaryngology, Ehime University School of Medicine, Toon, Japan.
  • Nibu KI; Department of Otolaryngology­Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan. Electronic address: nibu@med.kobe-u.ac.jp.
  • Inagaki H; Department of Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. Electronic address: hinagaki@med.nagoya-cu.ac.jp.
Oral Oncol ; 145: 106491, 2023 10.
Article in En | MEDLINE | ID: mdl-37487445
ABSTRACT
Adenoid cystic carcinoma (AdCC) of salivary gland grows relatively slowly, but occasionally develops distant metastasis. Although cervical lymph node metastasis (LNM) has been reported as a strong prognostic factor, most of AdCC do not have LNM. In this study, we investigated the prognostic factors to predict disease free survival (DFS), distant metastasis free survival (DMFS), and overall survival (OS) for 175 patients surgically treated for AdCC without LNM, and developed prognostic score (PS) determined as number of positive prognostic factors. The following emerged as significant prognostic factors positive surgical margin in DFS, pT3/4 and positive surgical margin in DMFS, and positive surgical margin and high-histological grade in OS. 10-year DFS rates were 56.4% in PS0, and 19.1% in PS1 (p < 0.0001). 10-year DMFS rates were 86.3% in PS0, 56.4% in PS1, and 30.7% in PS2 (p < 0.0001). 10-year OS rates were 100% in PS0, 73.3% in PS1, and 38.8% in PS2 (p < 0.0001).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Salivary Gland Neoplasms / Carcinoma, Adenoid Cystic Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Oral Oncol Journal subject: NEOPLASIAS Year: 2023 Document type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Salivary Gland Neoplasms / Carcinoma, Adenoid Cystic Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Oral Oncol Journal subject: NEOPLASIAS Year: 2023 Document type: Article Affiliation country: Japan