Advancing glioblastoma imaging: Exploring the potential of organic fluorophore-based red emissive carbon dots.
J Colloid Interface Sci
; 650(Pt B): 1619-1637, 2023 Nov 15.
Article
in En
| MEDLINE
| ID: mdl-37494859
ABSTRACT
Over time, the interest in developing stable photosensitizers (PS) which both absorb and emit light in the red region (650 and 950 nm) has gained noticeable interest. Recently, carbon dots (CDs) have become the material of focus to act as a PS due to their high extinction coefficient, low cytotoxicity, and both high photo and thermal stability. In this work, a Federal and Drug Association (FDA) approved Near Infra-Red (NIR) organic fluorophore used for photo-imaging, indocyanine green (ICG), has been explored as a precursor to develop water-soluble red emissive CDs which possess red emission at 697 nm. Furthermore, our material was found to yield favorable red-imaging capabilities of glioblastoma stem-like cells (GSCs) meanwhile boasting low toxicity. Additionally with post modifications, our CDs have been found to have selectivity towards tumors over healthy tissue as well as crossing the blood-brain barrier (BBB) in zebrafish models.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Glioblastoma
/
Quantum Dots
Limits:
Animals
Language:
En
Journal:
J Colloid Interface Sci
Year:
2023
Document type:
Article
Affiliation country:
United States