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Advancing glioblastoma imaging: Exploring the potential of organic fluorophore-based red emissive carbon dots.
Domena, Justin B; Ferreira, Braulio C L B; Cilingir, Emel K; Zhou, Yiqun; Chen, Jiuyan; Johnson, Qiaxian R; Chauhan, Bhanu P S; Bartoli, M; Tagliaferro, A; Vanni, Steven; Graham, Regina M; Leblanc, Roger M.
Affiliation
  • Domena JB; Department of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
  • Ferreira BCLB; Department of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
  • Cilingir EK; Department of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
  • Zhou Y; Department of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
  • Chen J; Department of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
  • Johnson QR; Department of Chemistry, William Paterson University of New Jersey, 300 Pompton Rd, Wayne, NJ 07470, USA.
  • Chauhan BPS; Department of Chemistry, William Paterson University of New Jersey, 300 Pompton Rd, Wayne, NJ 07470, USA.
  • Bartoli M; Department of Applied Science and Technology, Politecnico di Torino, Italy.
  • Tagliaferro A; Department of Applied Science and Technology, Politecnico di Torino, Italy.
  • Vanni S; Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; HCA Florida University Hospital, 3476 S University Dr, Davie, FL 33328, USA; Department of Medicine, Dr. Kiran C. Patel College of Allopathic Medicine, Davie, USA.
  • Graham RM; Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1475 NW 12th Ave, Miami, FL 33136, USA; Dr. Kiran C. Patel College of Allopathic Medicine, Ft. Lauderdale, F
  • Leblanc RM; Department of Chemistry, University of Miami, Coral Gables, FL 33146, USA. Electronic address: rml@miami.edu.
J Colloid Interface Sci ; 650(Pt B): 1619-1637, 2023 Nov 15.
Article in En | MEDLINE | ID: mdl-37494859
ABSTRACT
Over time, the interest in developing stable photosensitizers (PS) which both absorb and emit light in the red region (650 and 950 nm) has gained noticeable interest. Recently, carbon dots (CDs) have become the material of focus to act as a PS due to their high extinction coefficient, low cytotoxicity, and both high photo and thermal stability. In this work, a Federal and Drug Association (FDA) approved Near Infra-Red (NIR) organic fluorophore used for photo-imaging, indocyanine green (ICG), has been explored as a precursor to develop water-soluble red emissive CDs which possess red emission at 697 nm. Furthermore, our material was found to yield favorable red-imaging capabilities of glioblastoma stem-like cells (GSCs) meanwhile boasting low toxicity. Additionally with post modifications, our CDs have been found to have selectivity towards tumors over healthy tissue as well as crossing the blood-brain barrier (BBB) in zebrafish models.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glioblastoma / Quantum Dots Limits: Animals Language: En Journal: J Colloid Interface Sci Year: 2023 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glioblastoma / Quantum Dots Limits: Animals Language: En Journal: J Colloid Interface Sci Year: 2023 Document type: Article Affiliation country: United States