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Practical and Scalable Two-Step Process for 6-(2-Fluoro-4-nitrophenyl)-2-oxa-6-azaspiro[3.3]heptane: A Key Intermediate of the Potent Antibiotic Drug Candidate TBI-223.
Cardoso, Flavio S P; Kadam, Appasaheb L; Nelson, Ryan C; Tomlin, John W; Dahal, Dipendra; Kuehner, Christopher S; Gudvangen, Gard; Arduengo, Anthony J; Burns, Justina M; Aleshire, Sarah L; Snead, David R; Qu, Fengrui; Belmore, Ken; Ahmad, Saeed; Agrawal, Toolika; Sieber, Joshua D; Donsbach, Kai Oliver.
Affiliation
  • Cardoso FSP; Medicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States.
  • Kadam AL; Medicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States.
  • Nelson RC; Medicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States.
  • Tomlin JW; Medicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States.
  • Dahal D; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, United States.
  • Kuehner CS; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, United States.
  • Gudvangen G; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, United States.
  • Arduengo AJ; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, United States.
  • Burns JM; Medicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States.
  • Aleshire SL; Medicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States.
  • Snead DR; Medicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States.
  • Qu F; Department of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, Alabama 35487-0336, United States.
  • Belmore K; Department of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, Alabama 35487-0336, United States.
  • Ahmad S; Medicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States.
  • Agrawal T; Department of Chemistry, Virginia Commonwealth University, 1001 West Main Street, Richmond, Virginia 23284-3208, United States.
  • Sieber JD; Department of Chemistry, Virginia Commonwealth University, 1001 West Main Street, Richmond, Virginia 23284-3208, United States.
  • Donsbach KO; Medicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States.
Org Process Res Dev ; 27(7): 1390-1399, 2023 Jul 21.
Article in En | MEDLINE | ID: mdl-37496954

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Org Process Res Dev Year: 2023 Document type: Article Affiliation country: United States Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Org Process Res Dev Year: 2023 Document type: Article Affiliation country: United States Country of publication: United States