Recent Advances in Research on Active Compounds Against Hepatic Fibrosis.
Curr Med Chem
; 2023 Jul 27.
Article
in En
| MEDLINE
| ID: mdl-37497688
ABSTRACT
BACKGROUND:
Almost all chronic liver diseases cause fibrosis, which can lead to cirrhosis and eventually liver cancer. Liver fibrosis is now considered to be a reversible pathophysiological process and suppression of fibrosis is necessary to prevent liver cancer. At present, no specific drugs have been found that have hepatic anti-fibrotic activity.OBJECTIVE:
The research progress of anti-hepatic fibrosis compounds in recent ten years was reviewed to provide a reference for the design and development of anti-hepatic fibrosis drugs.METHODS:
According to the structure of the compounds, they are divided into monocyclic compounds, fused-heterocyclic compounds, and acyclic compounds.RESULTS:
In this article, the natural products and synthetic compounds with anti-fibrotic activity in recent ten years were reviewed, with emphasis on their pharmacological activity and structure-activity relationship (SAR).CONCLUSION:
Most of these compounds are natural active products and their derivatives, and there are few researches on synthetic compounds and SAR studies on natural product.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Curr Med Chem
Journal subject:
QUIMICA
Year:
2023
Document type:
Article
Affiliation country:
China