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Silk fibroin-based coating with pH-dependent controlled release of Cu2+ for removal of implant bacterial infections.
Lin, Tongyao; Zhang, Jinglin; Huo, Dongliang; Yang, Fengjuan; Zhang, Jingxian; Huang, Langhuan; Deng, Sui-Ping; Tan, Shaozao; Chen, Huifang.
Affiliation
  • Lin T; Guangdong Engineering & Technology Research Centre of Graphene-like Materials and Products, Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China.
  • Zhang J; Guangdong Engineering & Technology Research Centre of Graphene-like Materials and Products, Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China; School of Light Industry and Materials, Guangdong Polytechnic, Foshan 528041, China.
  • Huo D; Guangdong Engineering & Technology Research Centre of Graphene-like Materials and Products, Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China.
  • Yang F; Guangdong Engineering & Technology Research Centre of Graphene-like Materials and Products, Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China.
  • Zhang J; Guangdong Engineering & Technology Research Centre of Graphene-like Materials and Products, Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China.
  • Huang L; Guangdong Engineering & Technology Research Centre of Graphene-like Materials and Products, Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China.
  • Deng SP; Guangdong Engineering & Technology Research Centre of Graphene-like Materials and Products, Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China.
  • Tan S; Guangdong Engineering & Technology Research Centre of Graphene-like Materials and Products, Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China; Guangdong Jianpai New Materials Co., Ltd., Foshan 528500, China. Electronic address: tsztan@
  • Chen H; College of Pharmacy, Guangdong Lingnan Institute of Technology, Guangzhou 510663, China. Electronic address: chenhf_1968@163.com.
J Colloid Interface Sci ; 650(Pt B): 1893-1906, 2023 Nov 15.
Article in En | MEDLINE | ID: mdl-37517189
ABSTRACT
The implantation of medical devices is frequently accompanied by the invasion of bacteria, which may lead to implant failure. Therefore, an intelligent and responsive coating seems particularly essential in hindering implant-associated infections. Herein, a self-defensive antimicrobial coating, accompanied by silk fibroin as a valve, was successfully prepared on the titanium (Ti-Cu@SF) for pH-controlled release of Cu2+. The results showed that the layer could set free massive Cu2+ to strive against E. coli and S. aureus for self-defense when exposed to a slightly acidic condition. By contrary, a little Cu2+ was released in the physiological situation, which could avoid damage to the normal cells and showed excellent in vitro pH-dependent antibiosis. Besides, in vivo experiment confirmed that Ti-Cu@SF could work as an antibacterial material to kill S. aureus keenly and display negligible toxicity in vivo. Consequently, the design provided support for endowing the layer with outstanding biocompatibility and addressing the issue of bacterial infection during the implantation of Ti substrates.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Infections / Fibroins Limits: Humans Language: En Journal: J Colloid Interface Sci Year: 2023 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Infections / Fibroins Limits: Humans Language: En Journal: J Colloid Interface Sci Year: 2023 Document type: Article Affiliation country: China