Magnetic Resonance Imaging of Aerosol Deposition.
J Aerosol Med Pulm Drug Deliv
; 36(4): 228-234, 2023 08.
Article
in En
| MEDLINE
| ID: mdl-37523222
ABSTRACT
Nuclear magnetic resonance imaging (MRI) uses non-ionizing radiation and offers a host of contrast mechanisms with the potential to quantify aerosol deposition. This chapter introduces the physics of MRI, its use in lung imaging, and more specifically, the methods that are used for the detection of regional distributions of inhaled particles. The most common implementation of MRI is based on imaging of hydrogen atoms (1H) in water. The regional deposition of aerosol particles can be measured by the perturbation of the acquired 1H signals via labeling of the aerosol with contrast agents. Existing in vitro human and in vivo animal model measurements of regional aerosol deposition in the respiratory tract are described, demonstrating the capability of MRI to assess aerosol deposition in the lung.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Magnetic Resonance Imaging
/
Lung
Limits:
Animals
/
Humans
Language:
En
Journal:
J Aerosol Med Pulm Drug Deliv
Journal subject:
TERAPIA POR MEDICAMENTOS
Year:
2023
Document type:
Article
Affiliation country:
Canada