The curious case of IDH mutant acute myeloid leukaemia: biochemistry and therapeutic approaches.

Gruber, Emily; Kats, Lev M

Gruber, Emily; Kats, Lev M.

Affiliation

Gruber E; Peter MacCallum Cancer Centre and the Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3000, Australia.
Kats LM; Peter MacCallum Cancer Centre and the Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3000, Australia.

Biochem Soc Trans ; 51(4): 1675-1686, 2023 08 31.

Article in En | MEDLINE | ID: mdl-37526143

Subject(s)

Leukemia, Myeloid, Acute; Humans; Leukemia, Myeloid, Acute/drug therapy; Leukemia, Myeloid, Acute/genetics; Mutation; Ketoglutaric Acids; Cell Transformation, Neoplastic; Isocitrate Dehydrogenase/genetics

Key words

2-HG; IDH mutation; acute myeloid leukaemia; targeted therapies

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute Limits: Humans Language: En Journal: Biochem Soc Trans Year: 2023 Document type: Article Affiliation country: Australia Country of publication: United kingdom

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