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A Fluorogenic Disaccharide Substrate for α-Mannosidases Enables High-Throughput Screening and Identification of an Inhibitor of the GH92 Virulence Factor from Streptococcus pneumoniae.
Bhosale, Sandeep; Deen, Matthew C; Proceviat, Cameron; Hettle, Andrew; Winter, Dana K; Brockerman, Jacob; Levene, Marina; Bennet, Andrew J; Spino, Claude; Boraston, Alisdair B; Vocadlo, David J.
Affiliation
  • Bhosale S; Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
  • Deen MC; Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
  • Proceviat C; Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
  • Hettle A; Department of Biochemistry & Microbiology, University of Victoria, P.O. Box 3055 STN CSC, Victoria, British Columbia V8W 3P6, Canada.
  • Winter DK; Département de Chimie, Université de Sherbrooke, Sherbrooke, Québec J1K 2R1, Canada.
  • Brockerman J; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
  • Levene M; Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
  • Bennet AJ; Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
  • Spino C; Département de Chimie, Université de Sherbrooke, Sherbrooke, Québec J1K 2R1, Canada.
  • Boraston AB; Department of Biochemistry & Microbiology, University of Victoria, P.O. Box 3055 STN CSC, Victoria, British Columbia V8W 3P6, Canada.
  • Vocadlo DJ; Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
ACS Chem Biol ; 18(8): 1730-1737, 2023 08 18.
Article in En | MEDLINE | ID: mdl-37531094
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Streptococcus pneumoniae / Disaccharides Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Animals / Humans Language: En Journal: ACS Chem Biol Year: 2023 Document type: Article Affiliation country: Canada
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Streptococcus pneumoniae / Disaccharides Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Animals / Humans Language: En Journal: ACS Chem Biol Year: 2023 Document type: Article Affiliation country: Canada