A meta-analysis of the accuracy of Xpert MTB/RIF in diagnosing intestinal tuberculosis.
Lab Med
; 55(2): 238-244, 2024 Mar 07.
Article
in En
| MEDLINE
| ID: mdl-37531292
ABSTRACT
OBJECTIVE:
A detection method with high efficiency and accuracy is urgently needed in clinical work. The purpose of our study was to determine the diagnostic accuracy of the Xpert MTB/RIF assay for intestinal tuberculosis (ITB).METHODS:
We searched PubMed and 4 other databases from their establishment to July 19, 2022, for published essays of diagnostic performance in which Xpert MTB/RIF was used to test patients with clinically suspected ITB. An assessment of the quality of the selected literature was conducted using QUADAS-2. We built forest plots by MetaDiSc software.RESULTS:
The pooled Xpert MTB/RIF sensitivity was 48%, and the specificity was 99%. Moreover, the positive likelihood ratio for ITB diagnosis was 21.61. The negative likelihood ratio was 0.54. There were substantial variations between the study estimates of sensitivity (I2 = 87.6%) and specificity (I2 = 82.4%).CONCLUSION:
Intestinal TB is detected with limited diagnostic sensitivity by Xpert MTB/RIF but with high specificity. An Xpert-positive result may facilitate the rapid identification of ITB cases. Nevertheless, a negative result has less certainty in excluding the disease.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tuberculosis, Pulmonary
/
Antibiotics, Antitubercular
/
Mycobacterium tuberculosis
Type of study:
Diagnostic_studies
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Lab Med
Year:
2024
Document type:
Article
Affiliation country:
China