Microbial metabolite p-cresol inhibits gut hormone expression and regulates small intestinal transit in mice.
Front Endocrinol (Lausanne)
; 14: 1200391, 2023.
Article
in En
| MEDLINE
| ID: mdl-37534214
p-cresol is a metabolite produced by microbial metabolism of aromatic amino acid tyrosine. p-cresol and its conjugated forms, p-cresyl sulfate and p-cresyl glucuronide, are uremic toxins that correlate positively with chronic kidney disease and diabetes pathogenesis. However, how p-cresol affects gut hormones is unclear. Here, we expose immortalized GLUTag cells to increasing concentrations of p-cresol and found that p-cresol inhibited Gcg expression and reduced glucagon-like peptide-1 (GLP-1) secretion in vitro. In mice, administration of p-cresol in the drinking water for 2 weeks reduced the transcript levels of Gcg and other gut hormones in the colon; however, it did not affect either fasting or glucose-induced plasma GLP-1 levels. Furthermore, it did not affect glucose tolerance but promoted faster small intestinal transit in mice. Overall, our data suggest that microbial metabolite p-cresol suppresses transcript levels of gut hormones and regulates small intestinal transit in mice.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cresols
/
Glucagon-Like Peptide 1
Limits:
Animals
Language:
En
Journal:
Front Endocrinol (Lausanne)
Year:
2023
Document type:
Article
Affiliation country:
Denmark
Country of publication:
Switzerland