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MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC.
Zhao, Kaiqiang; Zheng, Mingyue; Su, Zezhuo; Ghosh, Shrestha; Zhang, Chao; Zhong, Wenzhao; Ho, Joshua Wing Kei; Jin, Guoxiang; Zhou, Zhongjun.
Affiliation
  • Zhao K; Medical Research Center, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, P.R. China; School of Biomedical Sciences, The University of Hong Kong, Hong Kong SAR, P.R. China; Centre for Regenerative Medicine and Health
  • Zheng M; Medical Research Center, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, P.R. China.
  • Su Z; School of Biomedical Sciences, The University of Hong Kong, Hong Kong SAR, P.R. China; Laboratory of Data Discovery for Health Limited (D24H), Hong Kong Science Park, Hong Kong SAR, P.R. China.
  • Ghosh S; School of Biomedical Sciences, The University of Hong Kong, Hong Kong SAR, P.R. China; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Zhang C; Guangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital & Guangdong Academy of Medical Sciences, Guangzhou 510080, P.R. China.
  • Zhong W; Guangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital & Guangdong Academy of Medical Sciences, Guangzhou 510080, P.R. China.
  • Ho JWK; School of Biomedical Sciences, The University of Hong Kong, Hong Kong SAR, P.R. China; Laboratory of Data Discovery for Health Limited (D24H), Hong Kong Science Park, Hong Kong SAR, P.R. China.
  • Jin G; Medical Research Center, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, P.R. China. Electronic address: gxjinking@163.com.
  • Zhou Z; Medical Research Center, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, P.R. China; School of Biomedical Sciences, The University of Hong Kong, Hong Kong SAR, P.R. China; Centre for Regenerative Medicine and Health
Cell Rep ; 42(8): 112939, 2023 08 29.
Article in En | MEDLINE | ID: mdl-37566546
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Non-Small-Cell Lung / Sirtuins / Lung Neoplasms Limits: Humans / Male Language: En Journal: Cell Rep Year: 2023 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Non-Small-Cell Lung / Sirtuins / Lung Neoplasms Limits: Humans / Male Language: En Journal: Cell Rep Year: 2023 Document type: Article