Transposon delivery for CRISPR-based loss-of-function screen in mice identifies NF2 as a cooperating gene involved with the canonical WNT signaling molecular class of hepatocellular carcinoma.

Keng, Vincent W; Chiu, Amy P; To, Jeffrey C; Li, Xiao-Xiao; Linden, Michael A; Amin, Khalid; Moriarity, Branden S; Yusa, Kosuke

Keng, Vincent W; Chiu, Amy P; To, Jeffrey C; Li, Xiao-Xiao; Linden, Michael A; Amin, Khalid; Moriarity, Branden S; Yusa, Kosuke.

Affiliation

Keng VW; The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen 518057, China.
Chiu AP; Department of Applied Biology and Chemical Technology, State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.
To JC; Department of Applied Biology and Chemical Technology, State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.
Li XX; The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen 518057, China.
Linden MA; Department of Applied Biology and Chemical Technology, State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.
Amin K; The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen 518057, China.
Moriarity BS; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Yusa K; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.

Heliyon ; 9(8): e18774, 2023 Aug.

Article in En | MEDLINE | ID: mdl-37576222

Key words

CRISPR/Cas9; CTNNB1; Hepatocellular carcinoma; NF2; Transposable elements

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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Heliyon Year: 2023 Document type: Article Affiliation country: China Country of publication: United kingdom

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