Performance of [18F]FDG PET/CT versus FAPI PET/CT for lung cancer assessment: a systematic review and meta-analysis.
Eur Radiol
; 34(2): 1077-1085, 2024 Feb.
Article
in En
| MEDLINE
| ID: mdl-37589901
ABSTRACT
PURPOSE:
This article aims to compare the diagnostic performance of 18-fluorodeoxyglucose ([18F]FDG) PET/CT and fibroblast activating protein inhibitor (FAPI) PET/CT in the assessment of primary tumors, lymph nodes, and distant metastases in lung cancer patients.METHODS:
A systematic search was conducted on the Cochrane Library, Embase, and PubMed/MEDLINE databases from inception until November 1, 2022. Included studies assessed the use of FAPI PET/CT and [18F]FDG PET/CT in patients with lung cancer. The Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool was used to evaluate the risk of bias. A random variable model was used to analyze the diagnostic tests of the two imaging modalities.RESULTS:
The sensitivity of FAPI PET/CT in detecting primary lung cancer lesions was 0.98 (95% CI 0.88-1.00), while the sensitivity of [18F]FDG PET/CT was 0.99 (95% CI 0.74-1.00). For the detection of metastatic lesions (lymph node metastases and distant metastases), FAPI PET/CT had a sensitivity of 0.99 (95% CI 0.90-1.00), while the sensitivity of [18F]FDG PET/CT was 0.77 (95% CI 0.66-0.85). However, the specificity of the two imaging modalities could not be assessed due to the lack of sufficient information on pertinent true negatives.CONCLUSION:
In the diagnosis of metastatic lung cancer lesions, FAPI PET/CT demonstrated a higher sensitivity compared to [18F]FDG PET/CT. Therefore, FAPI PET/CT may be considered an alternative imaging modality for the assessment of primary lung cancer tumors, lymph node metastases, and distant metastases. CLINICAL RELEVANCE STATEMENT FAPI may be an alternative to [18F]FDG in the assessment of primary lung cancer tumors, lymph node metastases, and distant metastases, which plays a very important role in treatment. KEY POINTS ⢠This article is to compare the performance of [18F]FDG PET/CT with FAPI PET/CT in the assessment of primary tumors, lymph nodes, and distant metastases in lung cancer. ⢠However, FAPI PET/CT has a higher sensitivity for the diagnostic assessment of metastatic lung cancer lesions.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Positron Emission Tomography Computed Tomography
/
Lung Neoplasms
Type of study:
Prognostic_studies
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Eur Radiol
Journal subject:
RADIOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
China