Visible-Light-Induced Reductive Coupling of Arylacetylenes with Benzothiazole Sulfones.
J Org Chem
; 88(17): 12776-12782, 2023 Sep 01.
Article
in En
| MEDLINE
| ID: mdl-37614008
In this study, we propose heavy-metal-free reductive coupling of arylacetylenes with benzothiazole sulfones. The reactions of alkyl or benzylic benzothiazole sulfones with arylacetylenes are successfully performed in the presence of Hantzsch esters and K2CO3 under visible-light irradiation to afford 1,2-disubstituted alkenes in moderate to good yields, with Z-isomer as the major product. The utility of this protocol is expanded to α-deuterative coupling using a deuterated Hantzsch ester, furnishing the corresponding alkenes with high deuterium incorporation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Org Chem
Year:
2023
Document type:
Article
Affiliation country:
Japan
Country of publication:
United States