Multiple LDLR class A repeats on very-low-density lipoprotein receptor promote the cross-species transmission of Semliki Forest virus.
MedComm (2020)
; 4(5): e351, 2023 Oct.
Article
in En
| MEDLINE
| ID: mdl-37614966
ABSTRACT
Multiple LDLR class A (LA) repeats around LA3 promote synergistic binding to Semliki Forest virus (SFV) E1-DIII near the 2-fold and 5-fold symmetry axes. Meanwhile, the multiple consecutive LAs concatemer shows approximately 1000 times higher binding affinity than that of LA3s, which can help to effectively and synergistically bind with E1-DIII of viral envelope protein.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
MedComm (2020)
Year:
2023
Document type:
Article