Epigallocatechin gallate circumvents drug-induced resistance in non-small-cell lung cancer by modulating glucose metabolism and AMPK/AKT/MAPK axis.

Zhou, Yan; Huang, Shiqi; Guo, Yizhen; Ran, Maoxin; Shan, Wenying; Chen, Wen-Hua; Tam, Kin Yip

Zhou, Yan; Huang, Shiqi; Guo, Yizhen; Ran, Maoxin; Shan, Wenying; Chen, Wen-Hua; Tam, Kin Yip.

Affiliation

Zhou Y; Faculty of Health Sciences, University of Macau, Taipa, Macau.
Huang S; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China.
Guo Y; Faculty of Health Sciences, University of Macau, Taipa, Macau.
Ran M; Faculty of Health Sciences, University of Macau, Taipa, Macau.
Shan W; Faculty of Health Sciences, University of Macau, Taipa, Macau.
Chen WH; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China.
Tam KY; Faculty of Health Sciences, University of Macau, Taipa, Macau.

Phytother Res ; 37(12): 5837-5853, 2023 Dec.

Article in En | MEDLINE | ID: mdl-37621136

Subject(s)

Carcinoma, Non-Small-Cell Lung; Lung Neoplasms; Humans; Animals; Mice; Carcinoma, Non-Small-Cell Lung/pathology; Proto-Oncogene Proteins c-akt/metabolism; AMP-Activated Protein Kinases; Lung Neoplasms/pathology; Cell Proliferation; Protein Kinase Inhibitors/pharmacology; Drug Resistance, Neoplasm; ErbB Receptors; Glucose/pharmacology; Cell Line, Tumor; Mutation

Key words

EGCG; EGFR-TKIs; NSCLC; acquired drug resistance; combination therapy; synergetic effect

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Non-Small-Cell Lung / Lung Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Phytother Res Journal subject: TERAPIAS COMPLEMENTARES Year: 2023 Document type: Article Affiliation country: Macao Country of publication: United kingdom

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