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A new secondary metabolite from the marine-derived fungus Phomopsis lithocarpus FS508.
Tan, Zi-Ling; Chen, Yu-Chan; Zhang, Jian-Peng; Liu, Hong-Xin; Zhang, Wei-Min; Yan, Han-Jing.
Affiliation
  • Tan ZL; School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China.
  • Chen YC; State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.
  • Zhang JP; State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.
  • Liu HX; School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China.
  • Zhang WM; State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.
  • Yan HJ; State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.
J Asian Nat Prod Res ; 26(4): 534-540, 2024 Apr.
Article in En | MEDLINE | ID: mdl-37639617
ABSTRACT
Based on the One Strain-Many Compounds (OSMAC) strategy, the secondary metabolites of Phomopsis lithocarpus FS508 were investigated. As a result, a new secondary metabolite, 4-methoxy-3-[4-(acetyloxy)-3-methyl-2-butenyl]benzoic acid (1) as well as eleven known compounds were isolated from the fermentation product of the strain FS508. Their structures were determined by NMR, IR, UV, and MS spectroscopic data analyses. All the isolated compounds were evaluated for cytotoxic and anti-inflammatory activities. Among them, compounds 3 and 9 displayed potent cytotoxicity against HepG-2 cell line, and compounds 2, 3 and 12 showed significant anti-inflammatory activities.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ascomycota / Antineoplastic Agents Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2024 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ascomycota / Antineoplastic Agents Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2024 Document type: Article Affiliation country: China