The impact of undergoing surgical margin evaluation during endoscopic surgery for early-stage laryngeal squamous cell carcinoma.
Head Neck
; 45(10): 2680-2689, 2023 10.
Article
in En
| MEDLINE
| ID: mdl-37642204
ABSTRACT
BACKGROUND:
The impact of evaluating versus not evaluating surgical margins for early-stage laryngeal squamous cell carcinoma (LSCC) has not been evaluated.METHODS:
Overall survival was compared between patients who underwent endoscopic surgery for cT1-2, N0, M0 LSCC and had surgical margins evaluated versus not evaluated versus unevaluable in the National Cancer Database (2010-2019) using multivariable-adjusted Cox proportional hazards analyses.RESULTS:
7597 patients met study eligibility criteria. 4123 (54.3%) patients underwent margin evaluation, 1631 (21.5%) did not undergo margin evaluation, and 1843 (24.3%) had unevaluable margins. Patients undergoing margin evaluation had better overall survival than patients who did not undergo margin evaluation (HR 0.88, 95% CI 0.78-1.00, p = 0.044) and patients with unevaluable margins (HR 0.88, 95% CI 0.78-0.98, p = 0.021). Patients undergoing margin evaluation received significantly less adjuvant radiation.CONCLUSIONS:
Surgical margin evaluation is an important prognostic factor for patients receiving endoscopic surgery for early-stage LSCC and should be conducted whenever possible.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Margins of Excision
/
Head and Neck Neoplasms
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Head Neck
Journal subject:
NEOPLASIAS
Year:
2023
Document type:
Article
Affiliation country:
United States