Stimuli-Responsive Non-viral Nanoparticles for Gene Delivery.
Handb Exp Pharmacol
; 284: 27-43, 2024.
Article
in En
| MEDLINE
| ID: mdl-37644142
ABSTRACT
Considering nucleic acids as the language of life and the genome as the instruction manual of cells, their targeted modulation promises great opportunities in treating and healing diseases. In addition to viral gene transfer, the overwhelming power of non-viral mRNA-based vaccines is driving the development of novel gene transporters. Thereby, various nucleic acids such as DNA (pDNA) or RNA (mRNA, siRNA, miRNA, gRNA, or ASOs) need to be delivered, requiring a transporter due to their high molar mass and negative charge in contrast to classical agents. This chapter presents the specific biological hurdles for using nucleic acids and shows how new materials can overcome these.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Nanoparticles
/
RNA, Guide, CRISPR-Cas Systems
Limits:
Humans
Language:
En
Journal:
Handb Exp Pharmacol
Year:
2024
Document type:
Article
Affiliation country:
Germany