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The Association between Dietary Sugar Intake and Nephrolithiasis: Results from National Health and Nutrition Examination Survey 2007-2018.
Zhang, Jiahao; Tang, Zhicheng; Lu, Zechao; Lin, Xuqing; Liao, Haiqin; Li, Zhibiao; Chen, Wanru; Hu, Chuxian; He, Zhaohui; Tang, Fucai.
Affiliation
  • Zhang J; Department of Urology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.
  • Tang Z; Department of Urology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.
  • Lu Z; Department of Urology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.
  • Lin X; The Second Clinical College of Guangzhou Medical University, Guangzhou, Guangdong, China.
  • Liao H; The Second Clinical College of Guangzhou Medical University, Guangzhou, Guangdong, China.
  • Li Z; Department of Urology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.
  • Chen W; The Third Clinical College of Guangzhou Medical University, Guangzhou, Guangdong, China.
  • Hu C; The Sixth Clinical College of Guangzhou Medical University, Guangzhou, Guangdong, China.
  • He Z; Department of Urology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China. Electronic address: hechh9@mail.sysu.edu.cn.
  • Tang F; Department of Urology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China. Electronic address: tangfc@mail.sysu.edu.cn.
J Nutr ; 153(10): 2968-2978, 2023 Oct.
Article in En | MEDLINE | ID: mdl-37648110
ABSTRACT

BACKGROUND:

Dietary sugar intake is gradually considered a risk factor for many diseases. A sugary diet was positively associated with risk of nephrolithiasis, but the specific relationships remain undefined.

OBJECTIVES:

To determine associations between risk of nephrolithiasis and dietary sugar intake.

METHODS:

This cross-sectional study involved 21,590 participants based on the National Health and Nutrition Examination Survey from 2007 to 2018. Amounts of dietary sugar intake (g/d) were the main exposure, including total sugar intake, added sugar intake, and food sources. Associations were analyzed by logistic regression models and restricted cubic splines using complex weighted designs.

RESULTS:

Weighted mean intake [standard error] of total sugar and added sugar were 111.2 [2.0] g/d and 73.7 [1.9] g/d in participants with nephrolithiasis, respectively. In the fully adjusted regression model, compared to those in quartile 1, the population in quartile 4 of total sugar intake showed a significant risk of nephrolithiasis [odds ratio (OR) 1.23; 95% confidence interval (CI) 1.00-1.51]; OR for added sugar intake was 1.56 (95% CI 1.25-1.94). The risks of nephrolithiasis increased steadily when total sugar and added sugar intake exceeded ∼150 g/d and 63 g/d in restricted cubic spline analyses, respectively. The highest sugar intake from beverages was associated with an increased risk of nephrolithiasis (OR for total sugar 1.36; 95% CI 1.07-1.72; OR for added sugar 1.37; 95% CI 1.09-1.73). Added sugar intake from meat, egg, and oil was significantly associated with risk of nephrolithiasis (quartile 4, OR 1.22; 95% CI 1.02-1.47), whereas total sugar intake from dairy products was in reverse (quartile 4, OR 0.67; 95% CI 0.54-0.82).

CONCLUSIONS:

Total and added sugar intake, sugar intake from beverages, and added sugar intake from meat, egg, and oil were associated with an increased risk of nephrolithiasis, whereas total sugar intake from dairy products was negatively associated.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Language: En Journal: J Nutr Year: 2023 Document type: Article Affiliation country: China

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Language: En Journal: J Nutr Year: 2023 Document type: Article Affiliation country: China