Development of pancreatic islet cells in the extrahepatic bile ducts of rats with experimentally-induced metabolic syndrome.
Arch Physiol Biochem
; : 1-9, 2023 Aug 31.
Article
in En
| MEDLINE
| ID: mdl-37651586
ABSTRACT
CONTEXT There is data about the existence of some endocrine cells in the epithelial layer of the bile duct in humans and rats. OBJECTIVE:
We evaluated Ghrelin-, Insulin-, Glucagon- and Somatostatin-positive cells in peribiliary glands, mast cells, and nerve fibres. MATERIALS ANDMETHODS:
Wistar rats were used for dietary manipulation with a 15% fructose solution for 12 weeks. Tissue samples were elaborated with immunohistochemistry for Insulin, Glucagon, Ghrelin, and Somatostatin. Glucose and lipid parameters were studied.RESULTS:
In treated animals, Ghrelin+ and Insulin+ cells in perybiliary glands (PBGs) were significantly increased. In the male fructose group there was a significant increase of the homeostasis model assessment insulin resistance (HOMA-IR).CONCLUSIONS:
Stem/progenitor cells in extrahepatic bile tree (EHBT) could be a source of Insulin-producing cells in metabolic syndrome. Fructose treatment induces the increase of Ghrelin+ and Insulin+ cells in PBGs and the elevation of Insulin and Ghrelin plasma concentration.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Arch Physiol Biochem
Journal subject:
BIOQUIMICA
/
FISIOLOGIA
Year:
2023
Document type:
Article
Affiliation country:
Bulgaria