Ribosome inactivation by Escherichia coli GTPase RsgA inhibits T4 phage.
Front Microbiol
; 14: 1242163, 2023.
Article
in En
| MEDLINE
| ID: mdl-37670987
ABSTRACT
Introduction:
Bacteria must combat phages, and myriad bacterial anti-phage systems have been discovered that reduce host metabolism, for example, by depleting energetic compounds like ATP and NAD+. Hence, these systems indirectly inhibit protein production. Surprisingly, direct reduction of ribosome activity has not been demonstrated to thwart phage.Methods:
Here, by producing each of the 4,287 Escherichia coli proteins and selecting for anti-phage activity that leads to enhanced growth, we investigated the role of host proteins in phage inhibition. Results anddiscussion:
We identified that E. coli GTPase RsgA inhibits lytic phage T4 by inactivating ribosomes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Front Microbiol
Year:
2023
Document type:
Article
Affiliation country:
United States