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Polyphenols Cause Structure Dependent Effects on the Metabolic Profile of Human Hepatocarcinogenic Cells.
Gerdemann, Andrea; Broenhorst, Melissa; Behrens, Matthias; Humpf, Hans-Ulrich; Esselen, Melanie.
Affiliation
  • Gerdemann A; Institute of Food Chemistry, University of Münster, Corrensstraße 45, 48149, Münster, Germany.
  • Broenhorst M; Institute of Food Chemistry, University of Münster, Corrensstraße 45, 48149, Münster, Germany.
  • Behrens M; Institute of Food Chemistry, University of Münster, Corrensstraße 45, 48149, Münster, Germany.
  • Humpf HU; Institute of Food Chemistry, University of Münster, Corrensstraße 45, 48149, Münster, Germany.
  • Esselen M; Institute of Food Chemistry, University of Münster, Corrensstraße 45, 48149, Münster, Germany.
Mol Nutr Food Res ; 67(21): e2300052, 2023 Nov.
Article in En | MEDLINE | ID: mdl-37672806
SCOPE: Although many beneficial health effects are attributed to polyphenols their influence on the human metabolome has not been elucidated yet. The ubiquitous occurrence of polyphenols in the human diet demands comprehensive knowledge about physiological and toxicological effects of these compounds on human cells. METHODS AND RESULTS: The human hepatocarcinogenic cell line HepG2 is used to elucidate the effects of 13 polyphenols and three respective phenolic degradation products on the human metabolome using HPLC-MS/MS. To investigate structure-activity-relationships, structurally related examples of polyphenols from different compound classes are selected. The analysis of catechins points toward a relation between the degree of hydroxylation and the extent of metabolic effects particularly on the urea cycle and the pentose phosphate pathway (PPP). A correlation between the modulation of the PPP and the stability of the compounds is demonstrated, which may be caused by reactive oxygen species (ROS). The incubation of flavones and alkenylbenzenes demonstrates reduced activity of methoxylated compounds and no impact of the B-ring position. CONCLUSION: In general, polyphenols induce a multitude of metabolic effects, for example, on energy metabolism, PPP, and urea cycle. These metabolic alterations may be related to the widely reported bioactivity of these compounds such as the anticarcinogenic effects.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Flavonoids / Polyphenols Limits: Humans Language: En Journal: Mol Nutr Food Res Journal subject: CIENCIAS DA NUTRICAO Year: 2023 Document type: Article Affiliation country: Germany Country of publication: Germany

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Flavonoids / Polyphenols Limits: Humans Language: En Journal: Mol Nutr Food Res Journal subject: CIENCIAS DA NUTRICAO Year: 2023 Document type: Article Affiliation country: Germany Country of publication: Germany