The separate axes of TECPR1 and ATG16L1 in CASM.
Autophagy
; 20(1): 214-215, 2024 01.
Article
in En
| MEDLINE
| ID: mdl-37676042
ABSTRACT
Conjugation of ATG8 to single membranes (CASM) is a fundamental cellular process that entails the conjugation of mammalian Atg8 homologs, here referred to as ATG8, to phosphatidylethanolamine (PE) and phosphatidylserine (PS) on endolysosomal compartments. Our current research, together with recent reports from the Randow, Wu, and Wileman labs, has uncovered yet another layer to this process. We discovered that, in addition to ATG16L1-containing complexes, TECPR1 (tectonin beta-propeller repeat containing 1)-containing ATG12-ATG5 E3 complexes can facilitate CASM, thereby providing a broader understanding of this pathway.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autophagy
/
Microtubule-Associated Proteins
Limits:
Animals
Language:
En
Journal:
Autophagy
Year:
2024
Document type:
Article
Affiliation country:
Norway