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GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.
Lagou, Vasiliki; Jiang, Longda; Ulrich, Anna; Zudina, Liudmila; González, Karla Sofia Gutiérrez; Balkhiyarova, Zhanna; Faggian, Alessia; Maina, Jared G; Chen, Shiqian; Todorov, Petar V; Sharapov, Sodbo; David, Alessia; Marullo, Letizia; Mägi, Reedik; Rujan, Roxana-Maria; Ahlqvist, Emma; Thorleifsson, Gudmar; Gao, Ηe; Εvangelou, Εvangelos; Benyamin, Beben; Scott, Robert A; Isaacs, Aaron; Zhao, Jing Hua; Willems, Sara M; Johnson, Toby; Gieger, Christian; Grallert, Harald; Meisinger, Christa; Müller-Nurasyid, Martina; Strawbridge, Rona J; Goel, Anuj; Rybin, Denis; Albrecht, Eva; Jackson, Anne U; Stringham, Heather M; Corrêa, Ivan R; Farber-Eger, Eric; Steinthorsdottir, Valgerdur; Uitterlinden, André G; Munroe, Patricia B; Brown, Morris J; Schmidberger, Julian; Holmen, Oddgeir; Thorand, Barbara; Hveem, Kristian; Wilsgaard, Tom; Mohlke, Karen L; Wang, Zhe; Shmeliov, Aleksey; den Hoed, Marcel.
Affiliation
  • Lagou V; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Jiang L; Human Genetics, Wellcome Sanger Institute, Hinxton, UK.
  • Ulrich A; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.
  • Zudina L; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
  • González KSG; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
  • Balkhiyarova Z; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
  • Faggian A; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.
  • Maina JG; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
  • Chen S; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.
  • Todorov PV; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Sharapov S; Department of Molecular Diagnostics, Clinical Laboratory, Clinica Biblica Hospital, San José, Costa Rica.
  • David A; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
  • Marullo L; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.
  • Mägi R; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK.
  • Rujan RM; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
  • Ahlqvist E; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.
  • Thorleifsson G; Laboratory for Artificial Biology, Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.
  • Gao Η; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.
  • Εvangelou Ε; UMR 8199-EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France.
  • Benyamin B; Section of Endocrinology and Investigative Medicine, Imperial College London, London, UK.
  • Scott RA; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
  • Isaacs A; Laboratory of Glycogenomics, Institute of Cytology and Genetics SD RAS, Novosibirsk, Russia.
  • Zhao JH; MSU Institute for Artificial Intelligence, Lomonosov Moscow State University, Moscow, Russia.
  • Willems SM; Centre for Bioinformatics and System Biology, Department of Life Sciences, Imperial College London, London, UK.
  • Johnson T; Department of Evolutionary Biology, Genetic Section, University of Ferrara, Ferrara, Italy.
  • Gieger C; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
  • Grallert H; Centre for Sports, Exercise and Life Sciences, Coventry University, Conventry, UK.
  • Meisinger C; Lund University Diabetes Centre, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
  • Müller-Nurasyid M; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.
  • Strawbridge RJ; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
  • Goel A; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
  • Rybin D; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
  • Albrecht E; Australian Centre for Precision Health, University of South Australia, Adelaide, South Australia, Australia.
  • Jackson AU; Allied Health and Human Performance, University of South Australia, Adelaide, South Australia, Australia.
  • Stringham HM; South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
  • Corrêa IR; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Farber-Eger E; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Steinthorsdottir V; CARIM School for Cardiovascular Diseases and Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, the Netherlands.
  • Uitterlinden AG; Department of Physiology, Maastricht University, Maastricht, the Netherlands.
  • Munroe PB; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Brown MJ; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Schmidberger J; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Holmen O; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.
  • Thorand B; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • Hveem K; German Center for Diabetes Research (DZD), Neuherberg, Germany.
  • Wilsgaard T; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.
  • Mohlke KL; German Center for Diabetes Research (DZD), Neuherberg, Germany.
  • Wang Z; Epidemiology, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
  • Shmeliov A; IBE, Faculty of Medicine, LMU Munich, Munich, Germany.
  • den Hoed M; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.
Nat Genet ; 55(9): 1448-1461, 2023 09.
Article in En | MEDLINE | ID: mdl-37679419
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 / Glucose Type of study: Clinical_trials / Prognostic_studies / Systematic_reviews Limits: Humans Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2023 Document type: Article Affiliation country: United kingdom Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 / Glucose Type of study: Clinical_trials / Prognostic_studies / Systematic_reviews Limits: Humans Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2023 Document type: Article Affiliation country: United kingdom Country of publication: United States