Hydrogen Peroxide Inhibits Hepatitis B Virus Replication by Downregulating HBx Levels via Siah-1-Mediated Proteasomal Degradation in Human Hepatoma Cells.

Yoon, Hyunyoung; Lee, Hye-Kyoung; Jang, Kyung Lib

Yoon, Hyunyoung; Lee, Hye-Kyoung; Jang, Kyung Lib.

Affiliation

Yoon H; Department of Integrated Biological Science, The Graduate School, Pusan National University, Busan 46241, Republic of Korea.
Lee HK; Department of Integrated Biological Science, The Graduate School, Pusan National University, Busan 46241, Republic of Korea.
Jang KL; Department of Integrated Biological Science, The Graduate School, Pusan National University, Busan 46241, Republic of Korea.

Int J Mol Sci ; 24(17)2023 Aug 28.

Article in En | MEDLINE | ID: mdl-37686160

Subject(s)

Carcinoma, Hepatocellular; Hepatitis B virus; Hepatitis B; Liver Neoplasms; Humans; Carcinoma, Hepatocellular/genetics; Hepatitis B virus/drug effects; Hydrogen Peroxide/pharmacology; Liver Neoplasms/genetics; Tumor Suppressor Protein p53/genetics; Virus Replication; Viral Regulatory and Accessory Proteins/drug effects; Trans-Activators/drug effects

Key words

HBx; Siah-1; hepatitis B virus; hydrogen peroxide; p53; proteasome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hepatitis B virus / Carcinoma, Hepatocellular / Hepatitis B / Liver Neoplasms Limits: Humans Language: En Journal: Int J Mol Sci Year: 2023 Document type: Article Country of publication: Switzerland

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