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Anti-HIV Drugs Reduce Risk of Prediabetes and Progression to Type 2 Diabetes in HIV-Infected Patients.
Magagnoli, Joseph; Pereira, Felipe; Narendran, Siddharth; Huang, Peirong; Cummings, Tammy; Hardin, James W; Nguyen, Joseph; Sutton, S Scott; Ambati, Jayakrishna.
Affiliation
  • Magagnoli J; Dorn Research Institute, Columbia VA Health Care System, Columbia, SC 29209.
  • Pereira F; Department of Clinical Pharmacy and Outcomes Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208.
  • Narendran S; Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA 22908.
  • Huang P; Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA 22908.
  • Cummings T; Departamento de Oftalmologia e Ciências Visuais, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil.
  • Hardin JW; Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA 22908.
  • Nguyen J; Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA 22908.
  • Sutton SS; Aravind Eye Hospital System, Madurai 625020, India.
  • Ambati J; Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA 22908.
MedComm Futur Med ; 2(2)2023 Jun.
Article in En | MEDLINE | ID: mdl-37692282
The aim of this study was to investigate whether the use of nucleoside reverse transcriptase inhibitors (NRTIs) impacts the incidence of prediabetes or type 2 diabetes mellitus (T2DM) or the progression from prediabetes to T2DM in people living with HIV (PLWH). We conducted a retrospective cohort study using the U.S. Veterans Health Administration database among adult patients with an HIV diagnosis from the year 2000 until 2021 to determine the incidence of prediabetes and further progression to T2DM among NRTI exposed and unexposed patients. A multistate model was used to evaluate progression from normoglycemia to prediabetes and then to T2DM, and covariate adjustment with the Cox proportional hazards model was used to estimate the hazard ratios. Among 32,240 veterans diagnosed with HIV, prediabetes and T2DM were observed among 20.2% and 20.7% of patients, respectively. Among those diagnosed with prediabetes, 31.8% progressed to T2DM. Patients exposed to NRTIs at any time (86.6%), had a reduced risk of prediabetes [HR 0.50 (0.47-0.53 95% CI)] and among prediabetics, a lower risk of progression to T2DM [HR 0.73 (0.63-0.85 95% CI)] when compared to patients who never used NRTIs. In summary, NRTIs may reduce the risk of developing prediabetes and the progression from prediabetes to T2DM in PLWH.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Etiology_studies / Observational_studies / Risk_factors_studies Language: En Journal: MedComm Futur Med Year: 2023 Document type: Article Country of publication: Australia

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Etiology_studies / Observational_studies / Risk_factors_studies Language: En Journal: MedComm Futur Med Year: 2023 Document type: Article Country of publication: Australia