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The bexarotene derivative OAB-14 ameliorates cognitive decline in APP/PS1 transgenic mice by suppressing microglia-mediated neuroinflammation through the PPAR-γ pathway.
Zhang, Feng; Cao, Ruo-Lin; Liu, Peng; Chi, Tian-Yan; Ji, Xue-Fei; Zheng, Zhong-Hui; Chen, Guo-Liang; Zou, Li-Bo.
Affiliation
  • Zhang F; Department of Pharmacology, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, PR China; Institute of Pharmacology, Shandong first Medical University, Jinan 250117, Shandong, PR China.
  • Cao RL; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, PR China.
  • Liu P; Department of Pharmacology, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, PR China.
  • Chi TY; Department of Pharmacology, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, PR China.
  • Ji XF; Department of Pharmacology, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, PR China.
  • Zheng ZH; Shandong Xinhua Pharmaceutical Co., Ltd., Zibo 255086, Shandong, PR China.
  • Chen GL; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, PR China. Electronic address: spucgl@163.com.
  • Zou LB; Department of Pharmacology, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, PR China. Electronic address: libozou@163.com.
Int Immunopharmacol ; 124(Pt A): 110911, 2023 Nov.
Article in En | MEDLINE | ID: mdl-37696142
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Int Immunopharmacol Journal subject: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Year: 2023 Document type: Article Country of publication: Netherlands
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Int Immunopharmacol Journal subject: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Year: 2023 Document type: Article Country of publication: Netherlands