Klebsiella pneumoniae: adaptive immune landscapes and vaccine horizons.
Trends Immunol
; 44(10): 826-844, 2023 10.
Article
in En
| MEDLINE
| ID: mdl-37704549
ABSTRACT
Klebsiella pneumoniae is among the most common antibiotic-resistant pathogens causing nosocomial infections. Additionally, it is a leading cause of neonatal sepsis and childhood mortality across the globe. Despite its clinical importance, we are only beginning to understand how the mammalian adaptive immune system responds to this pathogen. Further, many studies investigating potential K. pneumoniae vaccine candidates or alternative therapies have been launched in recent years. Here, we review the current state of knowledge on the adaptive immune response to K. pneumoniae infections and progress towards developing vaccines and other therapies to combat these infections.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Klebsiella Infections
/
Vaccines
Limits:
Animals
/
Child
/
Humans
/
Newborn
Language:
En
Journal:
Trends Immunol
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2023
Document type:
Article
Affiliation country:
United States