The Utility of Preclinical Models in Understanding the Bone Health of Transgender Individuals Undergoing Gender-Affirming Hormone Therapy.
Curr Osteoporos Rep
; 21(6): 825-841, 2023 Dec.
Article
in En
| MEDLINE
| ID: mdl-37707757
ABSTRACT
PURPOSE OF REVIEW To summarise the evidence regarding the effects of gender-affirming hormone therapy (GAHT) on bone health in transgender people, to identify key knowledge gaps and how these gaps can be addressed using preclinical rodent models. RECENT FINDINGS:
Sex hormones play a critical role in bone physiology, yet there is a paucity of research regarding the effects of GAHT on bone microstructure and fracture risk in transgender individuals. The controlled clinical studies required to yield fracture data are unethical to conduct making clinically translatable preclinical research of the utmost importance. Novel genetic and surgical preclinical models have yielded significant mechanistic insight into the roles of sex steroids on skeletal integrity. Preclinical models of GAHT have the potential inform clinical approaches to preserve skeletal integrity and prevent fractures in transgender people undergoing GAHT. This review highlights the key considerations required to ensure the information gained from preclinical models of GAHT are informative.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Fractures, Bone
/
Transgender Persons
Type of study:
Prognostic_studies
Aspects:
Determinantes_sociais_saude
/
Patient_preference
Limits:
Humans
Language:
En
Journal:
Curr Osteoporos Rep
Journal subject:
ORTOPEDIA
Year:
2023
Document type:
Article
Affiliation country:
Australia