Molecular design and synthesis of methoxy-substitued spiropyrans with photomodulated NIR-fluorescence.
Photochem Photobiol Sci
; 22(11): 2651-2673, 2023 Nov.
Article
in En
| MEDLINE
| ID: mdl-37733213
ABSTRACT
This study focuses on the molecular design and synthesis of salt spiropyrans with near-IR fluorescence. The structure of the obtained compounds was confirmed by NMR, IR and mass spectroscopy. In the course of studying the spectral and photoluminescent characteristics, it was possible to reveal the effect of some substituents in various positions on the properties of spiropyran dyes. Due to the structural similarity of one of the isomers to cyanine dyes, the obtained compounds are of interest as potential fluorescent probes for bioimagimg, in particular, for DNA studies. To reveal their ability of binding to DNA molecules molecular docking was carried out. Toxic effects of compounds demonstrating NIR fluorescence were studied on biofilms, as well as using bacterial lux-biosensors.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Benzopyrans
/
Fluorescent Dyes
Language:
En
Journal:
Photochem Photobiol Sci
Journal subject:
BIOLOGIA
/
QUIMICA
Year:
2023
Document type:
Article