Green synthesis of metal-organic framework loaded dexamethasone on wood aerogels for enhanced cranial bone regeneration.
J Mater Chem B
; 11(39): 9496-9508, 2023 10 11.
Article
in En
| MEDLINE
| ID: mdl-37740279
ABSTRACT
Bone defects have attracted increasing attention in clinical settings. To date, there have been no effective methods to repair defective bones. Balsa wood aerogels are considered as an excellent source of chemicals for chemical modification to facilitate the in situ immobilization of zeolitic imidazolate framework-8. Furthermore, dexamethasone has received considerable attention for bone tissue engineering. In this study, for the first time, a simple but effective one-pot method for developing a novel zeolitic imidazolate framework-8 with different concentrations of dexamethasone was developed. These findings illustrate that the novel scaffold has a significant positive impact on osteogenic differentiation in vitro and repairs defects in vivo, suggesting that it can be used in bone tissue engineering.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteogenesis
/
Metal-Organic Frameworks
Language:
En
Journal:
J Mater Chem B
Year:
2023
Document type:
Article
Affiliation country:
China