Brittle Bone Imaging: Diagnostic Procedures in Adults.
Semin Musculoskelet Radiol
; 27(4): 439-450, 2023 Aug.
Article
in En
| MEDLINE
| ID: mdl-37748467
ABSTRACT
This article concentrates on generalized disorders causing bone fragility. The most frequent cause of brittle bone disease is osteoporosis, only diagnosed by elimination. First, malignant osteopathy must be ruled out fracture on metastasis or multiple myeloma, which mimics osteoporosis when presenting as diffuse demineralization. Second, patients should be screened for signs of hyperparathyroidism or osteomalacia. Much more rarely, many other pathologies can lead to brittle bone by demineralization or associated increased bone density.The radiologist needs to know the clinical context and notably the patient's age (childhood or adulthood) at discovery, and known pathologies and ongoing or previous treatments corticotherapy, bisphosphonates, denosumab, or prior radiotherapy in the affected region. Diagnostic hypotheses are guided by the type of demineralization and the presence of lytic, mixed, or densifying areas. Lastly, the aspect and location of fractures and association with other bone abnormalities refine the diagnosis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteoporosis
/
Bone Diseases
/
Fractures, Bone
Type of study:
Diagnostic_studies
Limits:
Adult
/
Child
/
Humans
Language:
En
Journal:
Semin Musculoskelet Radiol
Journal subject:
FISIOLOGIA
/
ORTOPEDIA
/
RADIOLOGIA
Year:
2023
Document type:
Article
Affiliation country:
France