An active metabolite of the anti-COVID-19 drug molnupiravir impairs mouse preimplantation embryos at clinically relevant concentrations.

Marikawa, Yusuke; Alarcon, Vernadeth B

Marikawa, Yusuke; Alarcon, Vernadeth B.

Affiliation

Marikawa Y; Institute for Biogenesis Research, Department of Anatomy, Biochemistry and Physiology, University of Hawaii John A. Burns School of Medicine, Honolulu, HI 96813, USA.
Alarcon VB; Institute for Biogenesis Research, Department of Anatomy, Biochemistry and Physiology, University of Hawaii John A. Burns School of Medicine, Honolulu, HI 96813, USA. Electronic address: vernadet@hawaii.edu.

Reprod Toxicol ; 121: 108475, 2023 10.

Article in En | MEDLINE | ID: mdl-37748715

Subject(s)

COVID-19; Nucleosides; Pregnancy; Female; Mice; Animals; Nucleosides/metabolism; Nucleosides/pharmacology; Blastocyst; Hydroxylamines/metabolism; Hydroxylamines/pharmacology; Antiviral Agents/toxicity

Key words

Antiviral; Blastocyst; Developmental toxicity; Integrated stress response; Molnupiravir; N(4)-hydroxycytidine; Nucleoside transporter; Pregnancy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 / Nucleosides Limits: Animals / Pregnancy Language: En Journal: Reprod Toxicol Journal subject: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Year: 2023 Document type: Article Affiliation country: United States Country of publication: United States

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