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Heterologous DNA-prime/protein-boost immunization with a monomeric SARS-CoV-2 spike antigen redundantizes the trimeric receptor-binding domain structure to induce neutralizing antibodies in old mice.
Pflumm, Dominik; Seidel, Alina; Klein, Fabrice; Groß, Rüdiger; Krutzke, Lea; Kochanek, Stefan; Kroschel, Joris; Münch, Jan; Stifter, Katja; Schirmbeck, Reinhold.
Affiliation
  • Pflumm D; Department of Internal Medicine I, University Hospital of Ulm, Ulm, Germany.
  • Seidel A; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
  • Klein F; Department of Gene Therapy, University Hospital of Ulm, Ulm, Germany.
  • Groß R; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
  • Krutzke L; Department of Gene Therapy, University Hospital of Ulm, Ulm, Germany.
  • Kochanek S; Department of Gene Therapy, University Hospital of Ulm, Ulm, Germany.
  • Kroschel J; Institute of Clinical Chemistry, Ulm University Medical Center, Ulm, Germany.
  • Münch J; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
  • Stifter K; Department of Internal Medicine I, University Hospital of Ulm, Ulm, Germany.
  • Schirmbeck R; Department of Internal Medicine I, University Hospital of Ulm, Ulm, Germany.
Front Immunol ; 14: 1231274, 2023.
Article in En | MEDLINE | ID: mdl-37753087
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Group Antigens / Vaccines, DNA / COVID-19 Limits: Animals Language: En Journal: Front Immunol Year: 2023 Document type: Article Affiliation country: Germany Country of publication: Switzerland
Fulltext
Add to My VHL
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Group Antigens / Vaccines, DNA / COVID-19 Limits: Animals Language: En Journal: Front Immunol Year: 2023 Document type: Article Affiliation country: Germany Country of publication: Switzerland