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Anti-Inflammatory Halogenated Monoterpenes from the Red Alga Portieria hornemannii.
Wu, Yuan-Jhong; Huang, Tzu-Yin; Huang, Chiung-Yao; Lin, Chi-Chen; Wang, Wei-Lung; Huang, Hui-Chi; Liu, Shang-Yin Vanson; Chao, Chih-Hua; Sheu, Jyh-Horng.
Affiliation
  • Wu YJ; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
  • Huang TY; Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan.
  • Huang CY; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
  • Lin CC; Institute of Biomedical Science, National Chung Hsing University, Taichung 402, Taiwan.
  • Wang WL; Department of Biology, National Changhua University of Education, Changhua 500, Taiwan.
  • Huang HC; Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan.
  • Liu SV; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
  • Chao CH; School of Pharmacy, China Medical University, Taichung 404, Taiwan.
  • Sheu JH; Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan.
Mar Drugs ; 21(9)2023 Sep 14.
Article in En | MEDLINE | ID: mdl-37755106
ABSTRACT
The chemical investigation of a red alga Portieria hornemannii enabled the identification of three new halogenated monoterpenes (1-3) along with two previously identified metabolites (4 and 5). Their structures were determined by spectroscopic analysis and also by utilizing single-crystal diffraction analysis and quantum chemical calculation, as well as by comparison with literature data. Further corrections for dichloro and dibromo carbons using the sorted training set (STS) method were established in this study to significantly improve the accuracy in GIAO 13C NMR calculation of compounds 1-3. To discover the potential bioactive metabolites from P. hornemannii, the anti-inflammatory activities of all compounds were examined. Compounds 1 and 3-5 showed significant anti-inflammatory activity to inhibit the production of pro-inflammatory cytokines in the LPS-stimulated mature dendritic cells.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rhodophyta / Anti-Inflammatory Agents Language: En Journal: Mar Drugs Journal subject: BIOLOGIA / FARMACOLOGIA Year: 2023 Document type: Article Affiliation country: Taiwan
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rhodophyta / Anti-Inflammatory Agents Language: En Journal: Mar Drugs Journal subject: BIOLOGIA / FARMACOLOGIA Year: 2023 Document type: Article Affiliation country: Taiwan