Phage-Defense Systems Are Unlikely to Cause Cell Suicide.
Viruses
; 15(9)2023 Aug 24.
Article
in En
| MEDLINE
| ID: mdl-37766202
ABSTRACT
As new phage-defense systems (PDs) are discovered, the overlap between their mechanisms and those of toxin/antitoxin systems (TAs) is becoming clear in that both use similar means to reduce cellular metabolism; for example, both systems have members that deplete energetic compounds (e.g., NAD+, ATP) and deplete nucleic acids, and both have members that inflict membrane damage. Moreover, both TAs and PDs are similar in that rather than altruistically killing the host to limit phage propagation (commonly known as abortive infection), both reduce host metabolism since phages propagate less in slow-growing cells, and slow growth facilitates the interaction of multiple phage-defense systems.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Viruses
Year:
2023
Document type:
Article
Affiliation country:
United States