Detecting isolated cognitive relapses in persons with MS.
Mult Scler
; 29(14): 1786-1794, 2023 Dec.
Article
in En
| MEDLINE
| ID: mdl-37776097
ABSTRACT
BACKGROUND:
The existence of isolated cognitive relapses (ICRs) in persons with MS (PwMS) has been debated.OBJECTIVE:
To examine relapses with decline on Symbol Digit Modalities Test (SDMT) but no change on Expanded Disability Status Scale (EDSS).METHODS:
This 3-year prospective cohort study identified PwMS experiencing a relapse with decrease on SDMT. Participants with SDMT decline/stable EDSS were labeled "ICR," while those with a corresponding decrease on EDSS were classified "Relapse with Cognitive Decline (RCD)." Two definitions of SDMT decline were explored (1) ⩾ 8 points, and (2) ⩾ 4 points. Logistic regression was used to analyze the relationship between ICR and RCD.RESULTS:
The full cohort had 592participants:
83 experienced relapses; 22 (26.5%) had an SDMT decrease of ⩾ 8 points; 14 (63.6%) met ICR criteria. Logistic regression (X2(1) = 5.112, p = 0.024) using demographics and disease characteristics explained 28.4% of the variance in ICR versus RCD. Only the MS Neuropsychological Questionnaire was associated with ICR (odds ratio (OR) 8.6; 95% confidence interval (CI) 1.1-16.4) 40 relapsing participants with SDMT decrease of ⩾ 4 points were identified 26 (65%) had a stable EDSS (ICR). Logistic regression did not find any variable predictive of ICR.CONCLUSION:
This prospective study demonstrates evidence of ICR in PwMS.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cognitive Dysfunction
/
Multiple Sclerosis
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Mult Scler
Journal subject:
NEUROLOGIA
Year:
2023
Document type:
Article
Affiliation country:
Canada
Publication country:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM